The Skin Cancer Foundation Journal

MAY 2015

The 2012 edition of The Skin Cancer Foundation Journal features medically reviewed, reader-friendly articles such as tanning, the increasing incidence of skin cancer diagnoses among young women, & the prevalence of melanoma among white males over 50.

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Page 35 of 115

THE BENEFITS STILL PREVAIL RP, along with its fellow vitamin A deriv- atives, has been proven to increase collagen content and skin thickness, both classic fea- tures of healthy skin. In addition, it helps to regulate immune function in the skin, adding another level of defense against skin cancer. In cosmetic formulations, including sunscreens, this molecule is added in trace amounts as a stabilizer, protecting the product from light-induced breakdown. Dermatologists for decades have prescribed retinoids includ- ing RP for the treatment and prevention of numerous skin conditions, including precancerous skin lesions and skin cancers. Regular use of a topical retinoid ultimately improves the skin's ability to defend itself from the harmful rays of the sun. It is only during the initial weeks of starting a retinoid product that the skin becomes sun-sensitive, but once it is acclimated, the rejuvenated, more resilient epidermis, with potential precancers cleared away, will actually perform better under stress- ful environmental conditions including UV ra- diation. 1-4, 9 In other words, the many PROVEN benefits of retinoid use vastly outweigh the unproven risks suggested by an unpublished rodent study. LINDA FRANKS, MD, is Director of Gramercy Park Dermatology and a clinical assistant profes- sor of dermatology, New York University School of Medicine. She is a member of The Skin Cancer Foundation's Medical Council. PANTA ROUHANI SCHAFFER, MD, PHD, MPH, practices medical, cosmetic, and surgical dermatology as well as laser medicine at Gramercy Park Dermatology in New York City. She is a clini- cal assistant professor at the Ronald O. Perelman Department of Dermatology, New York University. References on pages 105-107. The Variations In Retinoids 34 *Requires a prescription Table 1. Sources of topical retinoids and the conditions they treat. ACTIVE INGREDIENT BRAND EXAMPLES FORMULATION INDICATION Retinyl esters - retinyl palmitate - retinyl propionate - retinyl acetate Retinol Retinaldehyde OTC brands as well as physician office-dispensed products. Common in cosmeceutical products. Various (0.05 %-0.3%) Photodamage Photoaging/Wrinkling Tretinoin* (all-transretinoic acid) Atralin Retin-A Retin-A Micro Renova Gel, cream, solution (0.1%, 0.05%, 0.04%, 0.025%, 0.02%, 0.01%) Acne Photoaging/Wrinkling Photodamage Tazarotene* (synthetic retinoic acid) Tazorac Avage Zorac Fabior Gel, cream (0.05%, 0.1%) Acne Psoriasis Photodamage Adapalene* (synthetic retinoic acid) Differin Gel, cream, lotion (0.1%, 0.3%) Acne Photoaging

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